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synotic | Pet Medications

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Synotic is used in the treatment of certain inflammatory conditions of the ear. It contains the corticosteroid fluocinolone, an anti-inflammatory medication. It also includes DMSO, which enhances the absorption of the fluocinolone and has anti-inflammatory properties.

For: Dogs



How it works: Synotic works by blocking the production of substances that trigger allergic and inflammatory responses in the ear.

Dosage & Administration: Synotic is given topically. The ear should be thoroughly cleaned and dried before treatment. Remove any debris, crusty material, etc., with a suitable non-irritating ear cleaning solution. Clip any excessive hair from the ear or treatment area, as directed.

Apply the prescribed amount in the ear and gently massage the ear to distribute the medication. Avoid contact with the eyes. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

Wear gloves when applying Synotic. Avoid contact with your bare skin. The DMSO is rapidly absorbed through the skin, enters the blood stream, and causes an unpleasant taste in the mouth for a short time. Avoid contact with the treated area until it has dried.

Do NOT give Synotic by mouth.

What happens if I miss a dose: If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

What happens if I overdose the pet: You may see an increase in the amount of drinking and urinating; loss of weight; panting; diarrhea and vomiting; or behavior changes. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.

Possible side effects of Synotic: DMSO may cause a garlic or oyster-like breath and taste in the mouth. Corticosteroids with DMSO may cause a short, stinging sensation, especially on open skin, and a temporary increase in temperature of the treated area may be noticed.

If ingested or given at high doses for an extended period of time, the most common side effect of corticosteroids with DMSO is an increase in the amount of drinking and urinating. Less commonly, you may see an increased appetite, a change in weight, panting, diarrhea, vomiting, and behavior changes. Consult your veterinarian if you notice any of the above side effects.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

What should I discuss with my veterinarian before using Synotic: If Synotic is to be used in the ear, your veterinarian should examine your pet's ear to make sure the ear drum is intact. Have your veterinarian or veterinary technician show you how to properly clean the ear and apply Synotic.


Have your veterinarian explain what results you can expect and when to call if improvement in the condition is not seen.

Notify your veterinarian of any other medications or supplements your dog is taking, and also if your dog has had any reactions to previous medications. Also tell your veterinarian if your pet is pregnant or nursing.


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