Price Comparisons for spironolactone



Spironolactone is a diuretic used to treat congestive heart failure and fluid accumulation in the abdomen (ascites).

For: Dogs & Cats


Used to treat congestive heart failure and ascites (fluid in the abdomen). It is often used when the pet does not respond to other diuretics. It does not cause the loss of potassium in the blood like other diuretics.

How it works: Spironolactone increases the excretion of water by the kidneys.

Dosage & Administration: Spironolactone is given orally. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.

Food may increase the absorption of Spironolactone. Consult your veterinarian about giving this medication with food.

This medication should only be given to the pet for whom it was prescribed.

Possible side effects of Spironolactone: May cause dehydration with excessive thirst and decreased urine production; or electrolyte imbalances (e.g., high potassium and low sodium), often with weakness, stumbling, or lack of energy. May cause vomiting and diarrhea in some animals. If you see any of these signs, contact your veterinarian immediately.

If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

If you miss giving a dose: If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.

If you overdose the pet: May see weakness, stumbling, lack of energy, vomiting, diarrhea, increased thirst, and changes in urination. If you observe any of these signs in your pet, contact your veterinarian immediately.


What should I avoid while giving Spironolactone to my pet: Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving Spironolactone.

Do not give with potassium supplements. If used with ACE inhibitors (heart medications such as enalapril or captopril), may increase the risk of high blood potassium levels.

May alter the level of the medication, digoxin, in the blood, and require extra monitoring of the blood levels of digoxin. Aspirin may decrease the effects of Spironolactone.


Who should not take it? Not for use in animals hypersensitive (allergic) to Spironolactone. Do not use in pregnant or lactating animals (female animals nursing their young). Do not use in animals with high potassium levels in the blood, or Addison's disease (hypoadrenocorticism).

Use with extreme caution in animals with liver or kidney disease. Do not use in animals with Cushing's disease (hyperadrenocorticism) who are taking the medication mitotane.