Doxepin is a orally administered, prescription medication that treats behavioral disorders in dogs and cats, including depression, noise phobia, and obsessive-compulsive disorder. Doxepin is also a potent antihistamine.
How it works: Doxepin blocks dopamine receptors in the central nervous system.
Dosage & Administration: Follow exact specifications prescribed by veterinarian.
The usual dosage is 0.25 to 0.5 mg per pound (0.5 to 1 mg/kg) orally, every 12 hours, or 1.5 to 2.5 mg per pound (3 to 5 mg/kg) orally every 8 to 12 hours.
Side Effects and Warnings Side effects include low blood pressure, high blood pressure, rapid heart rate, constipation, dry mouth, and blue-green urine. Doxepin should not be used in animals with known hypersensitivity or allergy to the drug, glaucoma or problems associated with urinary retention. Use with caution in seizure-prone animals.
Doxepin Interactions Notify your veterinarian of other medications that your pet is taking. Drug interactions occur with monoamine oxidase inhibitors, thyroid medications, atropine sedatives, antihistamines, norepinephrine and phenytoin. The following drugs may increase the effects of doxepin: cimetidine (Tagamet) estrogens fluoxetine (Prozac) some sedatives enalapril verapamil and ranitidine (Zantac).